Isoleucine (abbreviated as Ile or I)[1] is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)CH2CH3. It is an essential amino acid, which means that humans cannot synthesize it, so it must be ingested. Its codons are AUU, AUC and AUA.With a hydrocarbon side chain, isoleucine is classified as a hydrophobic amino acid. Together with threonine, isoleucine is one of two common amino acids that have a chiral side chain. Four stereoisomers of isoleucine are possible, including two possible diastereomers of L-isoleucine. However, isoleucine present in nature exists in one enantiomeric form, (2S,3S)-2-amino-3-methylpentanoic acid.
ITEM | STANDARD |
Appearance | White crystals or crystalline Powder |
Specific rotation | +38.6-+41.5 |
PH | 5.5-7.0 |
Loss on drying | ≤0.3% |
Heavy metals(Pb) | ≤20ppm |
Content | 98.5~101.0% |
Iron(Fe) | ≤20ppm |
Arsenic(As2O3) | ≤1ppm |
Lead | ≤10ppm |
Other Amino Acids | Chromatographically not detectable |
Residue on ignition (Sulfated) | ≤0.2% |
Organic Volatile impurities | Meets the requirements of pharmacopoeis |